Significant nucleophilic catalysis by chloride

stochastic growth dynamics and composite defects in quenched immiscible binary condensates

Analogues of 19 and 66 were prepared to investigate the SAR of these inhibitors. No improvements in activity or structural activity relationship (SAR) consistent with MDM2 binding were observed and no active analogues without the reactive functionality were found. These compound are no longer being investigated.Chapter 3 describes a 3 D shape based virtual screening campaign to find new lead compounds.

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